Reply: To solve the problem caused by the settings file saved for a game, just delete the directory where the settings file locates, and then reopen the game which will automatically generate a new settings file. Rest assured that this will not have any impact on your filing.

If you have a Windows XP system, the path is: (X is the disc of your system; your user name is your system account name)
X:\Documents and Settings\your user name\Local Settings\Application Data\Rockstar Games\GTA IV\


If you have a Windows 7 or Vista system, the path is:
X:\Users\your user name\AppData\Local\Rockstar Games\GTA IV\

Enter the game's settings directory according to the path, delete the "Settings" folder and all the files in it.

Delete: Settings folder in My Document\Rockstar Games\GTA IV

Then open the game again.

Reply: This is normal, as there is no such file after installation. You must find the corresponding launchgtaiv.exe to run the game.